Synthetic lethality induced by PARP inhibitors
「Synthetic lethality induced by PARP inhibitors」熱門搜尋資訊
「Synthetic lethality induced by PARP inhibitors」文章包含有：「BRCAness」、「PARPInhibitors」、「TheunderlyingmechanismforthePARPandBRCA...」、「Thesyntheticlethalityoftargetingcellcyclecheckpoints...」、「Syntheticlethaltherapiesforcancer」、「UnleashingthePowerofSyntheticLethality」、「Developmentofsyntheticlethalityincancer」、「Anewsyntheticlethalstrategyexpandstheapplicationof...」、「PARPinhibitorssuppresstumoursviacentrosomeerror...」
查看更多
BRCAness
https://www.jci.org
Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient cancer cells by inducing synthetic lethality, providing an effective biomarker-guided strategy for targeted cancer therapy.
PARP Inhibitors
https://www.ncbi.nlm.nih.gov
PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit ...
The underlying mechanism for the PARP and BRCA ...
https://www.ncbi.nlm.nih.gov
Poly (ADP‐ribose) polymerase (PARP) inhibitors effectively kill tumours defective in the BRCA1 or BRCA2 genes through the concept of synthetic lethality.
The synthetic lethality of targeting cell cycle checkpoints ...
https://jhoonline.biomedcentra
PARP inhibitors induce “synthetic lethality,” a mechanism introduced by geneticists a century ago whereby although one of two gene defects ...
Synthetic lethal therapies for cancer
https://www.nature.com
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance ... induced by PARP inhibition or PARP trapping on DNA.
Unleashing the Power of Synthetic Lethality
https://www.mdpi.com
PARP inhibitors specifically induce SL in cancer cells with defects in DNA homologous recombination. The black fork indicates that homologous recombination ...
Development of synthetic lethality in cancer
https://www.nature.com
The most remarkable finding in SL is the hypersensitivity of BRCA1/2-mutant tumor cells to poly-(ADP-ribose) polymerase (PARP) inhibitors.
A new synthetic lethal strategy expands the application of ...
https://onlinelibrary.wiley.co
Panel gene high-expression tumor cells are sensitive to PARP inhibitors/cisplatin treatment due to synthetic lethality caused by ribosomal ...
PARP inhibitors suppress tumours via centrosome error ...
https://www.thelancet.com
Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells. Elife. 2023; 12e80254.