Synthetic lethality induced by PARP inhibitors
「Synthetic lethality induced by PARP inhibitors」熱門搜尋資訊
![Synthetic lethality induced by PARP inhibitors](https://i0.wp.com/api.multiavatar.com/Synthetic+lethality+induced+by+PARP+inhibitors.png?apikey=viVnb6N20jclO8)
「Synthetic lethality induced by PARP inhibitors」文章包含有:「BRCAness」、「PARPInhibitors」、「TheunderlyingmechanismforthePARPandBRCA...」、「Thesyntheticlethalityoftargetingcellcyclecheckpoints...」、「Syntheticlethaltherapiesforcancer」、「UnleashingthePowerofSyntheticLethality」、「Developmentofsyntheticlethalityincancer」、「Anewsyntheticlethalstrategyexpandstheapplicationof...」、「PARPinhibitorssuppresstumoursviacentrosomeerror...」
查看更多![BRCAness](https://api.multiavatar.com/BRCAness%2C+DNA+gaps%2C+and+gain+and+loss+of+PARP+inhibitor+....png?apikey=viVnb6N20jclO8)
BRCAness
https://www.jci.org
Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient cancer cells by inducing synthetic lethality, providing an effective biomarker-guided strategy for targeted cancer therapy.
![PARP Inhibitors](https://api.multiavatar.com/PARP+Inhibitors%3A+The+First+Synthetic+Lethal+Targeted+Therapy.png?apikey=viVnb6N20jclO8)
PARP Inhibitors
https://www.ncbi.nlm.nih.gov
PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit ...
![The underlying mechanism for the PARP and BRCA ...](https://api.multiavatar.com/The+underlying+mechanism+for+the+PARP+and+BRCA+....png?apikey=viVnb6N20jclO8)
The underlying mechanism for the PARP and BRCA ...
https://www.ncbi.nlm.nih.gov
Poly (ADP‐ribose) polymerase (PARP) inhibitors effectively kill tumours defective in the BRCA1 or BRCA2 genes through the concept of synthetic lethality.
![The synthetic lethality of targeting cell cycle checkpoints ...](https://api.multiavatar.com/The+synthetic+lethality+of+targeting+cell+cycle+checkpoints+....png?apikey=viVnb6N20jclO8)
The synthetic lethality of targeting cell cycle checkpoints ...
https://jhoonline.biomedcentra
PARP inhibitors induce “synthetic lethality,” a mechanism introduced by geneticists a century ago whereby although one of two gene defects ...
![Synthetic lethal therapies for cancer](https://api.multiavatar.com/Synthetic+lethal+therapies+for+cancer%3A+what%27s+next+...+-+Nature.png?apikey=viVnb6N20jclO8)
Synthetic lethal therapies for cancer
https://www.nature.com
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance ... induced by PARP inhibition or PARP trapping on DNA.
![Unleashing the Power of Synthetic Lethality](https://api.multiavatar.com/Unleashing+the+Power+of+Synthetic+Lethality%3A+Augmenting+....png?apikey=viVnb6N20jclO8)
Unleashing the Power of Synthetic Lethality
https://www.mdpi.com
PARP inhibitors specifically induce SL in cancer cells with defects in DNA homologous recombination. The black fork indicates that homologous recombination ...
![Development of synthetic lethality in cancer](https://api.multiavatar.com/Development+of+synthetic+lethality+in+cancer%3A+molecular+....png?apikey=viVnb6N20jclO8)
Development of synthetic lethality in cancer
https://www.nature.com
The most remarkable finding in SL is the hypersensitivity of BRCA1/2-mutant tumor cells to poly-(ADP-ribose) polymerase (PARP) inhibitors.
![A new synthetic lethal strategy expands the application of ...](https://api.multiavatar.com/A+new+synthetic+lethal+strategy+expands+the+application+of+....png?apikey=viVnb6N20jclO8)
A new synthetic lethal strategy expands the application of ...
https://onlinelibrary.wiley.co
Panel gene high-expression tumor cells are sensitive to PARP inhibitors/cisplatin treatment due to synthetic lethality caused by ribosomal ...
![PARP inhibitors suppress tumours via centrosome error ...](https://api.multiavatar.com/PARP+inhibitors+suppress+tumours+via+centrosome+error+....png?apikey=viVnb6N20jclO8)
PARP inhibitors suppress tumours via centrosome error ...
https://www.thelancet.com
Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells. Elife. 2023; 12e80254.